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Researchers have learned a lot about why different strains of cannabis produce different effects

If you’ve used cannabis, you’ve certainly noticed that different strains of marijuana can produce drastically different effects. However, until recently, scientists did not know much about why this is the case. Recent research has led to marijuana news that has shed a lot of light on this phenomenon, which is now known to be caused by the fact that each strain has a unique mixture of more than 400 different compounds that are naturally present in cannabis.

What cannabinoids in marijuana affect the high?

In addition to THC (which causes most of marijuana’s psychoactive effects), CBD also has a major influence on the differences in the highs produced by different strains of marijuana, which has led to discoveries that have made headlines in marijuana news in recent times. CBD moderates negative effects from THC, such as anxiety and paranoia. The CBD content of marijuana varies greatly between indica and sativa strains. Indica strains can have high CBD levels, which can reach well over 1%. However, sativas often have low CBD levels, which can be as low as 0.6% or less. In addition, strains that are high in CBD often produce sedation as a result of the interaction between CBD and THC. However, there are some cannabis strains that have cannabis ruderalis in their genetics, which can have CBD contents that are significantly higher than either indica or sativa strains.

If a strain has high levels of CBD, some of the impairment on memory that THC can cause will be reduced as well. Furthermore, CBD stays in the body for a significant period of time, which means that it plays a role in the after-effects of marijuana. While the peak effects of CBD typically only last for 4-6 hours when it’s taken orally, some effects of CBD can continue for up to 24 hours, which can lead to a calmer and better mood the day after using strains of cannabis that are high in CBD.

However, strains that do not have high levels of CBD produce a high that’s primarily cerebral, which means that they tend to produce very little “couchlock”. In fact, they can even have uplifting and stimulating effects, which often make them best suited to daytime use.

It isn’t just CBD and THC that influence the high though, which is because there are several other important cannabinoids to be familiar with. One such cannabinoid is THCV, which tends to moderate the effects of THC in low doses. In fact, low doses of this compound actually bind to the same receptors as THC, which makes the effects of THC have less powerful effects on the brain. However, the effect is quite different when THCV is consumed in high doses. In fact, higher doses of THCV actually potentiate THC.

Not only that, but THCV causes appetite suppression. Therefore, strains that are high in this compound tend to produce less of the “munchies” than other strains of cannabis. However, THCV does not remain in the body as long as THC does, which means that it primarily tends to affect the beginning of the high. In most cases, the levels of this cannabinoid are quite low, which is often concentrations of under 1%.

However, THC levels in most professionally grown marijuana strains are 10-20% or even much higher, which means that the influence of THCV is usually minimal. However, there are certain strains that have high levels of it, which originally came from Africa. The concentrations of it in some of these marijuana plants can be well over 10%. One example of such a strain is Durban Poison.

Another cannabinoid that you should be familiar with is CBN, which impacts the high by causing sedation and reducing anxiety. The concentrations of this compound also tend to be quite low, which are generally less than 1%. However, the concentration of this compound does not remain constant as it slowly rises after a cannabis plant has been dried. That’s because THC breaks down into this compound, which means that older cannabis buds have larger amounts of it than freshly cut ones.

As a result, the effects of older marijuana buds tend to be more sedating and produce a somewhat less intense cerebral high than fresher cannabis. People who suffer from insomnia are likely to benefit greatly from strains that are high in this compound, which means that CBN-rich strains like Amsterdam Flame, Death Star, A-Dub, Pineapple Chunk, Cataract Kush, Kosher Kush, Shark Shock, and Blue Blood are likely to be highly effective for insomnia sufferers. Not only are these strains rich in CBN, but they also are CBD-rich indicas, which also contributes to their effectiveness for insomnia.

CBG is another cannabinoid that affects the high, which is due to its effects on the GABA system in the body. However, most strains do not contain high concentrations of this compound as it’s the precursor of both THC and CBD, which means that most cannabis breeders seek to create plants that efficiently break down this compound into either CBD or THC.

What about terpenes?

Many cannabis experts feel that terpenes play one of the most important roles in the differences in the effects of different strains of cannabis. However, cannabis plants often have terpene contents under 1%. However, the effects of these compounds are quite powerful despite the fact that they’re only found in low concentrations.

Myrcene is the predominant terpene in most strains of marijuana, and it tends to be present in concentrations of around 0.45-0.5%. The effects of this terpene tend to be sedating and can reduce anxiety, and it also contributes to the “couchlock” effect of strains that contain greater than 0.5% myrcene. Therefore, even sativa strains that are very high in THC do have compounds to offset the more mentally stimulating effects of THC, which is not only due to myrcene but other compounds that tend to offset the cerebral effects of THC.

However, other terpenes tend to have the opposite effect, such as limonene. Limonene is thought to act on the cannabinoid receptors in and of itself, which means that it can directly enhance the high. The effects of this terpene tend to be quite uplifting. It’s found in high concentrations in strains that have a hint of a citrus odor, and some examples of strains with lots of limonene are Lemon G, Hindu Kush, Dirty Girl, and Cinex.

β-Caryophyllene is another cannabis terpene, and it’s thought to affect the CB-2 receptors, which is similar to the effects of CBD on the body. As a result, it can help to mitigate some of the negative effects of THC, such as paranoia and anxiety. Pinene has similar effects, which can help to reduce THC side effects.

Phytol affects the GABA system in the body, and this reduces anxiety, which means that strains of marijuana rich in this cannabinoid can be more mellow than others in their effects. Nerolidol and linalool also help to promote relaxation, and the concentrations of these compounds vary considerably between different strains.


While researchers of the past considered THC to be solely or nearly solely responsible for the psychoactive effects of cannabis, further research in recent years has led to many discoveries about the effects of other cannabinoids on the high. These discoveries have led to marijuana news about why different high-THC strains of marijuana are capable of producing very different effects from one another. Not only that, but there’s likely to be more marijuana news about new discoveries that shed light on why different strains of cannabis produce different effects.


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