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What Canadians Need To Know About the New COVID-19 Vaccines

On November 9, U.S. pharmaceutical company Pfizer announced that its mRNA vaccine, which is being developed with German biotech company BioNTech, appears to protect against SARS-CoV-2, the virus that causes the COVID-19 infection.

Seven days later, Massachusetts-based Moderna reported that, according to preliminary findings, its own mRNA vaccine may be up to 94.5 per cent effective.

Then, more news: Pfizer gave an update that its vaccine had reached stage 3 clinical trial efficacy points. It concluded that its vaccine is 95 per cent effective and is beneficial to older people. The company said it would be applying to the U.S. FDA for emergency use authorization within days.

The back to back announcements have naturally generated considerable excitement. But its probably wise to leave the champagne corked for now. The findings are promising, says Susy Hota, an infectious disease specialist and the medical director of prevention and control at the University Health Network in Toronto. But there are still a few hurdles left to clear before the vaccines are made readily available.

Heres what you need to know about these vaccinesand when theyll be available to Canadians.

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Are these COVID-19 vaccines approved by Health Canada?

Both Pfizer and Moderna began their clinical trials in late July of this year. Pfizer enrolled nearly 44,000 participants, Moderna 30,000 participants. Part of the inclusion criteria for participants was that they had an appreciable risk of contracting the virus either because of where they lived or other circumstances. Each set of participants were divided into two groups: people who were given two doses of the vaccine and people who were given placebo or saltwater doses of the vaccine. Each trial was evaluated by an independent board of experts.

Health Canada is reportedly working directly with pharma companies like Moderna and Pfizer, getting the trial results as they become available in real-time rather than waiting for the studies to concludea situation which could potentially shorten the time for eventual approval here.

If the Pfizer and Moderna vaccines are approved by the FDA for emergency use, Hota doesnt think there would be a measurable lag between that and Health Canada approval.

It has to go through Health Canadas approval process, too, she says. But I dont think that is going to be a lengthy, difficult process.

Whats an mRNA vaccine, and how does it protect against the coronavirus?

Both the Pfizer and Moderna candidates are mRNA-based vaccinesa type of vaccine that uses genetic material to provoke an immune response against the virus in the body (rather than conventional vaccine formulations that use live or attenuated forms of the virus itself to fight infection).

RNA isa type of nucleic acidwe already have in our bodies. The Pfizer and Moderna vaccines work by injecting an mRNAcode that prompts the existing cellsofyour body to produce a replica of the spike protein that sits on top of the Sars-Cov2 virus. Your immune system recognizes that spike proteinas foreignandattacksit, says Hota.The immune system produces an army ofsoldiers that are primed to attack that spike protein should it appear in your body againas it would if you subsequently became infected with the virus.

An mRNA-based vaccine is an attractive option to fight the coronavirus because of its potency, its relative low cost, and its capacity for being developed and administered more rapidly in a lab than conventional vaccines.

There is an added wrinkle with the Pfizer vaccine, and thats storage. Its vaccine needs to be kept in very cold conditions, around -70C. That presents an extra layer of challenge when it comes to distribution as that puts most pharmacies and doctors offices out of the running. By contrast, Moderna says its vaccine can be refrigerated at -20 C, a temperature that makes it more likely to be distributed conventionally in doctors offices and pharmacies.

(Related: A Doctor Answers Your Questions on How Places Will Reopen During Covid-19)

How long do these COVID-19 vaccines protect you against infection?

The short answer: thats to be determined. Its not clear yet whether or not the vaccines offer lasting protection against the SARS-CoV-2 virus that causes COVID-19, or whether the immune response they generate lessens over time. Its also not firmly established whether or not the vaccines benefit most adults broadly or just certain groups. In its latest announcement, Pfizer indicated its vaccine is beneficial to people over 65 years old, but the clinical data supporting that claim hasnt been made readily available.

Time will also tell whether or not the vaccine offers protections to people whove had the virus before and if it can act to reduce the severity of the virus should someone get infected after being vaccinated.

Are they safe?

The preliminary findings in both trials suggest there are no significant safety concerns with either vaccine. That said, the data is still being collected and both companies intend to follow trial participants for a period of years.

That long-term follow-up is standard procedure with any new medication or therapy, says Hota. She doesnt see any red flags when it comes to safety but warns that the public should be primed for a few bumps in the road ahead. Its likely that over time we will learn which vaccines are better than others and that will be a longer process, she says.

The vaccines do appear to generate some side effects, including headache, soreness and fatigue. These kinds of side effects arent uncommon: the shingles vaccine can cause similar symptoms.

(Related: 4 Ways to Boost Your Mental Health During Covid-19)

When will the vaccines be rolled out across Canada?

That depends on when theyre approved by Health Canada. Prior to Pfizers update, Prime Minister Justin Trudeau had said he believes a vaccine could be available in Canada during the first three months of 2021. Its not clear if higher risk populations and health care workers in Canada would be given the vaccine earlier than that, but its fair to assume they would be first in line.

Canada has reached a deal with Pfizer to buy 20 million doses with options of up to 56 million additional doses (a total of 76 million doses). The government has a similar deal with Moderna for 20 million doses with options for up to 36 million additional doses (a total 56 million doses).

These two arent the only vaccines Canada is eyeing for use here.

A representative for the Government of Canadas Public Services and Procurement Department, which deals with the vaccines, confirmed that Canada currently has agreements with seven different companies, including Pfizer and Moderna.

What does this mean for us right now?

Aside from the much-needed mood-booster, not much more than a TBD Save the Date. Canada and much of the rest of the world is still in the middle of a pandemic and infections are growing exponentially. Canada currently has over 300,000 reported cases of coronavirus.

Were in for a long winter, and this is not the time to let your guard down. If you want to pop that champagne cork sometime in 2021, youd be well advised to continue to socially distance, reduce your contacts and wear a mask.

These public health measures are more important than ever now, says Hota.

Next: What the Anti-Mask Movement Needs to Know About COVID-19 

The post What Canadians Need To Know About the New COVID-19 Vaccines appeared first on Best Health Magazine Canada.

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